Scientists reverse aging-associated skin wrinkles and hair loss in a mouse model

Researchers have reversed wrinkled skin and hair loss, hallmarks of aging, in a mouse model. When a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, visible hair loss in a matter of weeks. When the mitochondrial function is restored by turning off the gene responsible for mitochondrial dysfunction, the mouse returns to smooth skin and thick fur, indistinguishable from a healthy mouse of the same age.

A gene mutation causes wrinkled skin and hair loss; turning off that mutation restores the mouse to normal appearance.

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